TWGFD

Welcome to 14-3-3 !

The 14-3-3 genes are first isolated from brain tissue, and they are strongly evolutionarily conserved across many different eukaryotic species, and play key roles in essential processes such as transcription, metabolism, intracellular trafficking, cell cycle regulation and signaling. 14-3-3 proteins are highly conserved small acidic proteins in different organisms, encoded by a large gene family (27-32 kDa). These proteins can form dimers (homo- or hetero- dimers) and have approximately nine antiparallel α-helices. These proteins also play vital roles in metabolic and regulatory pathways in plants, controlling the generation of adenosine-triphosphate, the metabolism of nitrogen and carbon, germination and other essential processes.