TWGFD

Welcome to C2H2-ZFP !

The zinc finger proteins (ZFPs) are one of the largest protein families in plants. These proteins harbor a highly conserved domain, in which a zinc ion is surrounded by cysteine (Cys) and/or histidine (His) residues to stabilize their three-dimensional structure, comprising a two-stranded antiparallel beta sheets and a helix. Based on the number and location of these Cys and His residues, the ZFPs can be divided into ten classes: C2H2 (TFIIIA), C2HC (Retroviral nucleocapsid), C2HC5 (LIM domain), C2C2, C3H (Nup 475), C3HC4 (RING finger), C4 (GATA-1), C4HC3 (Requium), C6 (GAL4), and C8 (Steroid-thyroid receptor). The members of these classes play crucial roles in plant growth and development, as well as in signal transduction and environmental stress responses.