TWGFD

Welcome to CBFB-NFYA !

Nuclear factor Y (NF-Y), also named Heme activator protein (HAP) or CCAAT-binding factor (CBF), is a heterotrimeric transcription factor present in nearly all eukaryotes that includes at least three subunits: NF-YA (CBF-B or HAP2), NF-YB (CBF-A or HAP3), and NF-YC (CBF-C or HAP5). The NF-Y protein has been found to bind specifically to CCAAT motifs in eukaryotic promoter regions and affect downstream gene transcription. In animals, yeast, and plants, each NF-Y subunit contains highly evolutionarily conserved domains for DNA-binding and subunit interaction, allowing the formation of the heterotrimeric NF-Y complex. Each NF-Y subunit is encoded by a single gene in yeast and mammals but by a multigene family in plants.