TWGFD

Welcome to CIPKs !

CBL-interacting protein kinases (CIPKs) have been shown to play crucial roles in plant developmental processes, hormone signaling transduction, and in the response to abiotic stress. CBL-interacting protein kinases (CIPKs) can specifically target CBLs to transduce the perceived calcium signal, belonging to the Ca2+-mediated CBL-CIPK network, in response to various stimuli. CIPK proteins are composed of an N-terminal kinase domain and a C-terminal regulatory domain. In the C-terminal regulatory domain, the conserved NAF or FISL motif is responsible for interacting with Ca2+-bound CBLs, leading to the activation of the targeting CIPKs. In addition, the protein-phosphatase interaction (PPI) domain within the C-terminus of CIPKs can also target specific members of the protein phosphatase 2C.