TWGFD

Welcome to HD-ZIP !

Homeobox proteins are a large superfamily of transcription factors (TFs) found in invertebrates, vertebrates, fungi, and plants, which contain a highly conserved DNA-binding domain known as the homeodomain (HD). The HD is 60 amino acids in length and adopts a structure of three α-helices connected by a loop and a turn. The HD binds DNA as a monomer with high affinity through the interactions established by helix III (called the recognition helix) with the major groove of the target DNA while the disordered N-terminal arm, located upstream the first helix, interacts with the DNA minor groove. The homeodomain-leucine zipper (HD-Zip) gene family, whose members play vital roles in plant growth and development, and participate in responding to various stresses, is an important class of transcription factors currently only found in plants.