TWGFD

Welcome to MLO !

Powdery mildew is an airborne plant disease widespread in temperate climates that is caused by ascomycete fungi of the order Erysiphales and that can cause significant harvest losses in field-crops, fruit crops, and ornamental plants. The Mildew resistance locus O (MLO) gene family is a subject of intense research because some of its members have proved to confer a durable resistance to powdery mildew in several crop species. MLO genes are present as small families in the genomes of all higher plant species, both monocots and dicots. MLO proteins contains topological signature of seven transmembrane domains with an extracellular amino-terminus and intracellular carboxy-terminus which harbours a calmodulin binding domain to sense the calcium oscillations within the cell. MLO proteins are characterized by the presence of seven transmembrane domains and are localized to plasma membrane.