TWGFD

Welcome to NBS-LRR !

Resistance (R) genes have been shown frequently by classic genetics to be single loci that confer resistance against pathogens that express matching avirulence genes in a “gene-for-gene” manner. The plant resistance response triggered by R gene recognition also includes increased expression of defense genes, generation of reactive oxygen species, production or release of salicylic acid, ion fluxes, and other factors. The largest class of known R proteins includes those that contain a nucleotide binding site and leucine-rich repeat domains (NBS-LRR proteins). NBS-LRR proteins may recognize the presence of the pathogen directly or indirectly. The NBS-LRR R proteins contain distinct domains, several of which are composed of characteristic motifs. Nucleotide binding sites are found in diverse proteins and are required for ATP and GTP binding.