TWGFD

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NODULE-INCEPTION-like proteins (NLPs) are conserved, plant-specific transcription factors, their proteins presented a homology to NIN not only in the RWP-RK domain but also in N-terminal regions. NLP proteins contain two major conserved domains, the RWP-RK and PB1 (Phox and Bem1) domains. The RWP-RK domain functions in the DNA binding domain whose activity is unrelated to nitrate signaling, whereas the N-terminal regions of NLPs function as a transcriptional activation domain that mediates this signaling, and the PB1 domain is involved in protein-protein interactions. NLP family of transcription factors were identified as nitrate-responsive cis-element (NRE)-binding proteins, which function as transcriptional activators in the nitrate-regulated expression of downstream genes.