TWGFD

Welcome to SWEET !

The SWEET (sugars will eventually be exported transporter) family, a novel family of sugar transporters, can mediate the diffusion of sugars across intracellular or plasma membranes and exhibits low sugar affinity. The transport activities of SWEET proteins for both cellular uptake and efflux of various mono- and di-saccharides are dependent neither on proton gradient nor on pH, suggesting that they are energy-independent uniporters. SWEETs are widely distributed in prokaryotes, plants and animals, and most of them comprise seven transmembrane helices (7-TMHs) harboring two conserved MtN3/saliva domains, and each domain is a triple helix bundle (THB) formed by the three TM helices (3-TMHs). Many SWEET genes have been well studied in plants, and are considered to play key roles in the regulation of plant growth and development such as phloem loading, nectar secretion, pollen development, and seed filling.