TWGFD

Welcome to WD40 !

WD40 proteins, also known as WD-repeat proteins or WD40-containing proteins, comprise one of the largest protein families in eukaryotes, but they are rare in prokaryotes. WD40 protein was first identified and analyzed as a G protein β-subunit (bovine transducin β-subunit), containing repeated units of ~43 residues with conserved Glycine Histidine (GH) and tryptophan aspartate (WD) motifs. WD40 proteins function as scaffolds for protein-protein interactions or provide platforms to recruit diverse molecules that form functional complexes. WD40 proteins play vital roles in many basic biological processes, such as DNA replication, transcriptional regulation and damage responses, RNA processing and modification, protein degradation, histone recognition and modification, apoptosis and signal transduction.