TWGFD

Welcome to ZF-HD !

Zinc finger homeodomain (ZHD) TFs, harboring a homeodomain (HD) and a C2H2-type zinc finger motif (ZF), are involved in plant development and stress responses. The HD is a DNA-binding domain containing approximately 60 amino acids that is present in numerous transcription factors in all eukaryotic organisms. HD proteins participate widely in development by regulating the expression patterns of target genes in both plants and animals. Most HD proteins are associated with additional domain(s) or motifs for protein-protein interactions and/or other regulatory functions. HD-containing proteins are classified into six distinct families based on the presence of different motifs: leucine zipper-associated HD (HD-Zip), zinc finger motif-associated HD (ZF-HD), WUSCHEL-related homeobox (WOX), Bell type HD, finger domain associated to a HD (PHD finger), and Knotted-related homeobox (KNOX) proteins.